Studies investigating glutathione depletion, oxidative stress, inflammation, and metabolic health in individuals with Type 2 diabetes. This research demonstrated improvements in glutathione status while supporting healthy antioxidant and immune function.
These findings suggest potential therapeutic benefits of L-GSH supplementation in conjunction with first-line antibiotic therapy against M. tb infection in individuals with T2DM.
We report that L-GSH supplementation for 3 months in people with T2DM was able to reduce the levels of oxidative stress in all blood components and prevent depletion of glutathione (GSH) in this population known to be GSH deficient.
Overall, the findings suggest that lower levels of GSH in individuals with T2DM lead to their increased susceptibility to M. tb infection.