The Paper and addendum address the loss of GSH that occurs with Covid-19.
Paper: Glutathione Supplementation as an Adjunctive Therapy in COVID-19 (1)
Addendum: SARS-CoV-2 and COVID-19
During infection with Covid-19, loss of GSH begins with the attachment of the S protein to cells. Severe acute respiratory syndrome (SARS) coronaviruses contain a protein (N protein) that helps the virus replicate. N protein programs an infected cell to produce immune hormones (cytokines) known as IL-6 and TGF?. IL-6 depletes GSH in cells including lung cells and TGF? is well characterized to compromise GSH production. Both IL-6 and TGF? have been shown in clinical studies to predict a more severe progression of Covid-19 symptoms. This information may explain why Covid-19 has led to severe illness in some individuals, especially those with conditions associated with low GSH.
ReadiSorb® Liposomal Glutathione (RLG) has been shown in clinical studies to safely and effectively restore GSH to normal in individuals with depleted GSH from the virus HIV in adults and in children with autism (2-4).
1. Guloyan V, Oganesian B, Baghdasaryan N, Yeh C, Singh M, Guilford F, et al. Glutathione Supplementation as an Adjunctive Therapy in COVID-19. Antioxidants (Basel). 2020;9(10). https://www.ncbi.nlm.nih.gov/pubmed/32992775
2. Kern JK, Geier DA, Adams JB, Garver CR, Audhya T, Geier MR. A clinical trial of glutathione supplementation in autism spectrum disorders. Med Sci Monit. 2011;17(12):CR677-82. http://www.ncbi.nlm.nih.gov/pubmed/22129897
3. Ly J, Lagman M, Saing T, Singh MK, Tudela EV, Morris D, et al. Liposomal Glutathione Supplementation Restores TH1 Cytokine Response to Mycobacterium tuberculosis Infection in HIV-Infected Individuals. J Interferon Cytokine Res. 2015;35(11):875-87. PMCID: 4642835. http://www.ncbi.nlm.nih.gov/pubmed/26133750
4. Valdivia A, Ly J, Gonzalez L, Hussain P, Aing T, Islamoglu H, et al. Restoring cytokine balance in HIV Positive Individuals with Low CD4 T Cell Counts. AIDS Res Hum Retroviruses. 2017. http://www.ncbi.nlm.nih.gov/pubmed/28398068